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05952cam a2200409 i 4500 |
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NSK01000172515 |
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HR-ZaNSK |
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20090526113627.0 |
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960918s1996 ci a m 000 0 hrv |
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|9 (HR-ZaNSK)172717
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|9 (HR-ZaNSK)960918002
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|a (HR-ZaNSK)000172515
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|a HR-ZaNSK
|b hrv
|c HR-ZaNSK
|e ppiak
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0 |
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|a hrv
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| 044 |
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|a ci
|c hr
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| 080 |
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|a 618.14-006-091.8
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| 100 |
1 |
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|a Ilić-Forko, Jadranka
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| 245 |
1 |
0 |
|a Odnos histoloških karakteristika i steroidnih receptora karcinoma endometrija :
|b doktorska disertacija /
|c Jadranka Ilić-Forko.
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| 260 |
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|a Zagreb :
|b J. Ilić-Forko,
|c 1996
|e ([s. l. :
|f s. n.])
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| 300 |
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|a 85 listova :
|b table, graf. prikazi ;
|c 30 cm.
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| 502 |
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|a Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, 1996
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| 504 |
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|a Bibliografija: str. 67-84
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| 504 |
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|a Summary
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| 520 |
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|a Sažetak: Analizirano je 117 bolesnica s karcinomom endometrija s ciljem da se odredi povezanost receptorskog statusa i histoloških karakteristika (tip karcinoma, zrelost tumora, zrelost stanica, dubina invazije miometrija, broja mitoza, prisutnost nekroze, te saćastih i upalnih stanica u stromi tumora), kao i značenje pojedinih histoloških parametara i receptorskog statusa u predmnijevanju ishoda bolesti. Pokazano je da vrijednost, koja najbolje razgraničava vjerovatnost preživljenja "cut off" za ER iznosi 10 fmol/mg, a za PR 25 fmol/mg proteina. Histološki tip i zrelost karcinoma, kao i zrelost stanica, te broj mitoza statistički su značajno povezani s receptorskim statusom.
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| 520 |
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|a Karcinomi povoljnog histološkog tipa (endometrioidni sa svojim podvarijantama i mucinozni) značajno su češće receptor pozitivni nego karcinomi nepovoljnog histološkog tipa (adenoskvamozni, serozni i klarocelularni) (p[0.01). Dobro diferencirani karcinomi (p[0.0001), karcinomi građeni pretežno od zrelijih stanica (p[0.00001), te karcinomi s manjim brojem mitoza (p[0.01) također značajno češće imaju pozitivne receptore. Između receptorskog statusa i dubine invazije, te nekroze, kao i prisutnosti upalnih i saćastih stanica u stromi tumora ne postoji statistički značajna povezanost.
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| 520 |
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|a Univarijatnom analizom našli smo da statistički značajno na prognozu utječu histološki tip karcinoma (p[0.0001), zrelost karcinoma određena na temelju arhitekture (p[0.001), izgled jezgara (p[0.0001) ili na temelju oba ova parametra (p[0.0001), broj mitoza (p[0.01), dubina invazije miometrija (p[0.001), zrelost stanica - značajka temeljena na odnosu jezgre i citoplazme (p[0.0001), ER (p[0.001), PR (p[0.01), te ERPR (p[0.0001). Multivarijatnom analizom statističku značajnost za prognozu bolesnica s karcinomom endometrija ima samo zrelost stanica (p[0.05).
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| 520 |
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|a Bez obzira što se ER i PR nisu multivarijatnom analizom pokazali statistički značajnim za prognozu bolesnica s karcinomom endometrija, oni statistički značajno utječu na preživljenje unutar podskupina bolesnica s nepovoljnim histološkim tipom (p[0.05), bolesnica s karcinomom arhitekturalnog gradusa 2 (p[0.01), FIGO gradusa 3 (p[0.05), kod invazije u srednju trećinu miometrija (p[0.01), te u bolesnica s karcinomima kod kojih je broj mitoza 5-10/ 10 VVP (p[0.01).
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| 520 |
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|a Summary: The aim of this study was to determine the association of the receptor status and histological characteristics (histological type, grade of tumor differentiation, maturity of tumor cells, depth of myometrial invasion, number of mitoses, presence of necrosis and presence of foamy and inflammatory cells in the tumor) and prognostic importance of histological parameters and receptor status. For this purpose 117 patients with endometrial carcinoma were analysed. The cut off value of 10fmol/mg for ER and 25 fmol/mg for PR was shown to be the best border for the likelihood of survival.
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| 520 |
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|a Histological type of carcinoma , its grade of differentiation, maturity of tumor cells and number of mitoses showed significant association with receptor status. Carcinomas of the "favourable" histological type (endometrioid carcinoma and its subtypes and mucinous carcinoma) showed receptor positivity significantly more often than carcinomas of the "unfavourable" histological type (adenosquamous, serous and clear cell carcinoma) (p[0,01).Carcinomas with better differentiation (p[0,0001), more mature cells (p[0,00001) and lower number of mitoses (p[0,01) were also receptor positive significantly more often.
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| 520 |
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|a There was no significant association between the receptor status and depth of myometrial invasion, presence of necrosis and presence of foamy or inflammatory cells in the tumor stroma. By univariate analysis, significant influence on prognosis was shown for: fistological type (p[0,0001) and the grade of differentiation assessed by architectural (p[0,001) and nuclear (p[0,0001) grade or both ways (p[0,0001).
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| 520 |
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|a The same was found also for number of mitoses (p[0,01), depth of myometrial invasion (p[0,001), maturity of tumor cells- the parameter based on nuclear/cytoplasmic ratio (p[0,0001), ER (p[0,001), PR (p[0,01) and both ER and PR (p[0,0001). The only prognostic factor shown to have significant influence on survival by multivariate analysis was maturity of tumor cells. Although ER and PR showed no significant influence on prognosis by multivariate analysis, they influenced significantly the survival of patients with: unfavourable histologic type of carcinoma (p[0,05), carcinomas of architectural grade 2 (p[0,01) and FIGO grade 3 (p[0,05), carcinomas invading the middle third of myometrium (p[0,01) and in patients that had carcinoma showing 5-10 mitoses/ 10 HPF (p[0,01).
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| 650 |
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7 |
|a Maternica
|x Karcinom
|x Histopatologija
|2 nskps
|
| 981 |
|
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|p CRO
|r HRB1996
|
| 998 |
|
|
|n DCD
|c sbno9802
|c rjkp9803
|c sbni9806
|
| 852 |
4 |
|
|j DCD-ZG-142/96
|
| 876 |
|
|
|e DCD
|a 142/1996
|
| 886 |
0 |
|
|2 unimarc
|b 05676iam0 2200337 450
|