Cytotoxicity of selected pyridinium oximes in human SH-SY5Y neuroblastoma cell line
Summary: Pyridinium oximes are pharmacologically important nucleophylic agents acting as effective antidotes against poisoning by organophosphorus compounds that inhibit acetylcholinesterase (AChE; EC 3.1.1.7.). In this study, the cytotoxicity of 1-phenacylpyridinium-4-aldoxime chloride (FEPA-4) was...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000710072/Details |
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| Matična publikacija: |
Croatica chemica acta 81 (2008), 1 ; str. 67-71 |
| Glavni autor: | Kalanj Bognar, Svjetlana (-) |
| Ostali autori: | Foretić, Blaženka (-), Vukelić, Željka, Gulin, Tonko, Ježek, Davor |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
CROATICA CHEMICA ACTA |
| LEADER | 02351caa a2200361 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000710072 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20150330130843.0 | ||
| 007 | ta | ||
| 008 | 090819s2008 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)712621 | ||
| 035 | |a (HR-ZaNSK)000710072 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 080 | |a 57 |2 MRF 1998. | ||
| 080 | |a 54 |2 MRF 1998. | ||
| 080 | |a 616 |2 MRF 1998. | ||
| 100 | 1 | |a Kalanj Bognar, Svjetlana | |
| 245 | 1 | 0 | |a Cytotoxicity of selected pyridinium oximes in human SH-SY5Y neuroblastoma cell line / |c Svjetlana Kalanj Bognar, Blaženka Foretić, Željka Vukelić, Tonko Gulin and Davor Ježek. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 15 jed | ||
| 504 | |a Sažetak | ||
| 520 | 8 | |a Summary: Pyridinium oximes are pharmacologically important nucleophylic agents acting as effective antidotes against poisoning by organophosphorus compounds that inhibit acetylcholinesterase (AChE; EC 3.1.1.7.). In this study, the cytotoxicity of 1-phenacylpyridinium-4-aldoxime chloride (FEPA-4) was analyzed in human SH-SY5Y neuroblastoma cell line highly expressing acetylcholinesterase. The concentrations of 0.5, 1, 2 and 4 mmol dm–3 and time-dependent effects at 1, 3, 6, 12 and 24 hours were tested in comparison with non-treated cells. In addition, neuroblastoma cells were treated with a well known antidote 1,1'-bis(pyridinium-4-aldoxime)trimethylene dibromide (TMB-4) at the concentration of 0.8 mmol dm–3, the highest studied concentration which in several non-neural cellular models induced no cytotoxicity. Cytotoxic effects i.e. altered cellular morphology and decreased cellular volume density quantified by stereological method were observed in FEPA-4 treated cells, while no cytotoxic effect was observed for 0.8 mmol dm–3 TMB-4. Possible mechanisms of observed FEPA-4 cytotoxicity in neuroblastoma cells are discussed | |
| 653 | |a Piridinski oksimi |a Citotoksičnost |a Humani neuroblastom | ||
| 700 | 1 | |a Foretić, Blaženka | |
| 700 | 1 | |a Vukelić, Željka | |
| 700 | 1 | |a Gulin, Tonko | |
| 700 | 1 | |a Ježek, Davor | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 81 (2008), 1 ; str. 67-71 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B02/08 |p CRO | ||
| 998 | |a rado090819 |c mzoo120312 | ||
| 856 | 4 | 2 | |u http://public.carnet.hr/ccacaa/ |y CROATICA CHEMICA ACTA |