Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells
Summary: After 24- and 48-hour treatment with 0.05, 0.5 and 5 mg/mL of fumonisin (FB1), beauvericin (BEA) and ochratoxin A (OTA) alone or combinations of two or all three mycotoxins in equal concentrations, Giemsa-stained binucleated PK15 cells were scored for the presence of micronuclei (MN), nucle...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000710126/Details |
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| Matična publikacija: |
Croatica chemica acta 81 (2008), 1 ; str. 139-146 |
| Glavni autor: | Šegvić Klarić, Maja (-) |
| Ostali autori: | Pepeljnjak, Stjepan (-), Rozgaj, Ružica |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
CROATICA CHEMICA ACTA |
| LEADER | 02235caa a2200337 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000710126 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20120313131341.0 | ||
| 007 | ta | ||
| 008 | 090820s2008 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)712675 | ||
| 035 | |a (HR-ZaNSK)000710126 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 080 | |a 57 |2 MRF 1998. | ||
| 080 | |a 616 |2 MRF 1998. | ||
| 080 | |a 59 |2 MRF 1998. | ||
| 100 | 1 | |a Šegvić Klarić, Maja | |
| 245 | 1 | 0 | |a Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells : |b effects of individual and combined treatment / |c Maja Šegvić Klarić, Stjepan Pepeljnjak and Ružica Rozgaj. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 44 jed | ||
| 504 | |a Sažetak | ||
| 520 | 8 | |a Summary: After 24- and 48-hour treatment with 0.05, 0.5 and 5 mg/mL of fumonisin (FB1), beauvericin (BEA) and ochratoxin A (OTA) alone or combinations of two or all three mycotoxins in equal concentrations, Giemsa-stained binucleated PK15 cells were scored for the presence of micronuclei (MN), nuclear buds (NBs) and nucleoplasmic bridges (NPBs). Single mycotoxins induced MN and NPBs in a dose-dependent manner, showing predominantly clastogenic effect. OTA showed stronger genotoxic potential than FB1 and BEA, since 0.05 and 0.5 mg/mL OTA increased the frequency of MN and NPBs, respectively. Mycotoxin combinations increased the frequency of MN and NPBs, mostly in additive manner. A dose-dependent increase in NBs was observed after 24-hour exposure to single mycotoxins. Prolonged treatment with 5 mg/mL of each toxin alone as well as combined exposure to all mycotoxin concentrations resulted in a decrease in NBs, which could be related to the extrusion of micronuclei and/or saturation of the genotoxic effect. This is the first report on genotoxicity of BEA | |
| 653 | |a Mikotoksini |a Genotoksičnost |a Bubrežni epitel svinje | ||
| 700 | 1 | |a Pepeljnjak, Stjepan | |
| 700 | 1 | |a Rozgaj, Ružica | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 81 (2008), 1 ; str. 139-146 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B02/08 |p CRO | ||
| 998 | |a rado090820 |c mzoo120313 | ||
| 856 | 4 | 2 | |u http://public.carnet.hr/ccacaa/ |y CROATICA CHEMICA ACTA |