Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
Abstract: Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto the mercury...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000716611/Details |
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| Matična publikacija: |
Croatica chemica acta 81 (2008), 3 ; str. 453-459 |
| Glavni autor: | Nigović, Biljana (-) |
| Ostali autori: | Komorsky-Lovrić, Šebojka (-), Devčić Stanković, Dubravka |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
CROATICA CHEMICA ACTA |
| LEADER | 02196caa a2200325 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000716611 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20220322152708.0 | ||
| 007 | ta | ||
| 008 | 091020s2008 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)719181 | ||
| 035 | |a (HR-ZaNSK)000716611 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 080 | |a 54 |2 MRF 1998. | ||
| 080 | |a 615 |2 MRF 1998. | ||
| 100 | 1 | |a Nigović, Biljana | |
| 245 | 1 | 0 | |a Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid / |c Biljana Nigović, Šebojka Komorsky-Lovrić, Dubravka Devčić. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 20 jed | ||
| 504 | |a Sažetak | ||
| 520 | 8 | |a Abstract: Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 × 10–8 to 7.5 × 10–7 mol L–1, with detection limit of 4.5 × 10–9 mol L–1. Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined | |
| 653 | 0 | |a Antilipemici |a Simvastatin |a Enzimi |a Reduktaza |a Voltametrija |a Abrazivna voltametrija |a Pravokutnovalna voltametrija | |
| 700 | 1 | |a Komorsky-Lovrić, Šebojka | |
| 700 | 1 | |a Devčić Stanković, Dubravka | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 81 (2008), 3 ; str. 453-459 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B09/08 |p CRO | ||
| 998 | |a rado091020 |c vol2o120830 | ||
| 856 | 4 | 2 | |u http://public.carnet.hr/ccacaa/ |y CROATICA CHEMICA ACTA |