Modelling of ICAM-1 and LFA-1 interaction using molecular recognition theory
Summary: The model of ICAM-1 and LFA-1 molecular interaction was used to test the application of the Molecular Recognition Theory for the identification of several discontinuous binding regions, i.e. ligand-receptor sites, within large antigenic molecules. Molecular Recognition Theory is an applicab...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000717390/Details |
|---|---|
| Matična publikacija: |
Croatica chemica acta 81 (2008), 2 ; str. 283-287 |
| Glavni autor: | Štambuk, Nikola (-) |
| Ostali autori: | Konjevoda, Paško (-), Vikić-Topić, Dražen, Pokrić, Biserka |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
CROATICA CHEMICA ACTA |
| LEADER | 02225caa a2200337 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000717390 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20190701170808.0 | ||
| 007 | ta | ||
| 008 | 091027s2008 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)719964 | ||
| 035 | |a (HR-ZaNSK)000717390 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 080 | |a 54 |2 MRF 1998. | ||
| 100 | 1 | |a Štambuk, Nikola | |
| 245 | 1 | 0 | |a Modelling of ICAM-1 and LFA-1 interaction using molecular recognition theory / |c Nikola Štambuk, Paško Konjevoda, Dražen Vikić-Topić, Biserka Pokrić. |
| 300 | |b Ilustr. | ||
| 500 | |a 22nd Dubrovnik International Course & Conference MATH / CHEM / COMP 2007, Dubrovnik, June 11–16, 2007 | ||
| 504 | |a Bibliografija: 23 jed. | ||
| 504 | |a Sažetak | ||
| 520 | 8 | |a Summary: The model of ICAM-1 and LFA-1 molecular interaction was used to test the application of the Molecular Recognition Theory for the identification of several discontinuous binding regions, i.e. ligand-receptor sites, within large antigenic molecules. Molecular Recognition Theory is an applicable heuristic algorithm for identification of possibly interacting amino acid pairs in short linear epitope/paratope sites within larger molecules. However, in order to achieve better efficiency this heuristic algorithm of molecular recognition has to be combined to several other procedures: molecular hydropathy analyses, secondary structure prediction methods and protein database search. The limitation of the combined MRT-hydropathy analyses is in the fact that it cannot explain 3D protein interactions, but it can be a valuable starting point for a more complex computational and experimental analysis | |
| 653 | 0 | |a Aminokiseline |a Ligand |a Receptori |a Antigeni |a Bjelančevine |a Interakcije |a Molekularno modeliranje |a Molekularno prepoznavanje |a Eksperimentalna analiza | |
| 700 | 1 | |a Konjevoda, Paško | |
| 700 | 1 | |a Vikić-Topić, Dražen | |
| 700 | 1 | |a Pokrić, Biserka | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 81 (2008), 2 ; str. 283-287 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B10/08 |p CRO | ||
| 998 | |a rado091027 |c vol2o120829 |b mili1907 | ||
| 856 | 4 | 2 | |u http://public.carnet.hr/ccacaa/ |y CROATICA CHEMICA ACTA |