Expression of MAGE-A1, MAGE-A3/4 and NY-ESO-1 cancer-testis antigens in fetal testis

Summary: Immunohistochemical expression of MAGE-A1, MAGE-A3/4 and NY-ESO-1/LAGE-1 cancer testis antigens (CTA) was assessed in 24 fetal testes from 15th to 36th week of gestation. Three monoclonal antibodies were used for immunohistochemical staining: 77B recognizing MAGE-A1, 57B recognizing multipl...

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Matična publikacija: Acta dermatovenerologica Croatica
17 (2009), 2 ; str. 103-107
Glavni autor: Hudolin, Tvrtko (-)
Ostali autori: Kaštelan, Željko (-), Derežić, Daniel, Bašić-Jukić, Nikolina, Spagnoli, Giulio C., Juretić, Antonio, Ježek, Davor
Vrsta građe: Članak
Jezik: eng
Predmet:
Online pristup: Acta Dermatovenerologica Croatica
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245 1 0 |a Expression of MAGE-A1, MAGE-A3/4 and NY-ESO-1 cancer-testis antigens in fetal testis /  |c Tvrtko Hudolin, Željko Kaštelan, Danijel Derežić, Nikolina Bašić-Jukić, Giulio Cesare Spagnoli, Antonio Juretić, Davor Ježek. 
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504 |a Bibliografija: 11 jed 
520 8 |a Summary: Immunohistochemical expression of MAGE-A1, MAGE-A3/4 and NY-ESO-1/LAGE-1 cancer testis antigens (CTA) was assessed in 24 fetal testes from 15th to 36th week of gestation. Three monoclonal antibodies were used for immunohistochemical staining: 77B recognizing MAGE-A1, 57B recognizing multiple MAGE-A CTA, and D8.38 recognizing NY-ESO-1/ LAGE-1. Expression of MAGE-A1 was not observed in fetal testis samples, whereas multi-MAGE-A and NY-ESO-1/LAGE-1 specific reagents stained pro-spermatogonia in all samples with different expression levels during the period of fetal development observed. Significant expression of MAGEA3/ 4 and almost continuous expression of NY-ESO-1 in fetal testes after 22nd week of gestation suggested their important role in the development of sex cords and pro-spermatogonia in particular 
653 0 |a MAGE-A  |a NY-ESO-1  |a Antigen  |a Rak testisa 
700 1 |a Kaštelan, Željko 
700 1 |a Derežić, Daniel 
700 1 |a Bašić-Jukić, Nikolina 
700 1 |a Spagnoli, Giulio C. 
700 1 |a Juretić, Antonio 
700 1 |a Ježek, Davor 
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