Structure of the T6 human nickel insulin derivative at 1.35 A resolution
Summary: This paper presents results of the structural investigation on the human insulin hexamer derivative stabilised by nickel coordination. Single crystals of the Ni-insulin derivative were prepared by the hanging drop vapour diffusion crystallisation method using metal-free insulin and nickel(I...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000734635/Details |
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| Matična publikacija: |
Croatica chemica acta 82 (2009), 2 ; str. 433-438 |
| Glavni autor: | Prugovečki, Biserka (-) |
| Ostali autori: | Dodson, Eleanor J. (-), Dodson, Guy G., Matković-Čalogović, Dubravka |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
Croatica Chemica Acta |
| LEADER | 01959caa a2200313 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000734635 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20211005152045.0 | ||
| 007 | ta | ||
| 008 | 100426s2009 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)737257 | ||
| 035 | |a (HR-ZaNSK)000734635 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 042 | |a croatica | ||
| 080 | |a 54 |2 MRF 1998. | ||
| 080 | |a 577 |2 MRF 1998. | ||
| 100 | 1 | |a Prugovečki, Biserka | |
| 245 | 1 | 0 | |a Structure of the T6 human nickel insulin derivative at 1.35 A resolution / |c Biserka Prugovečki, Eleanor J. Dodson, Guy G. Dodson, and Dubravka Matković-Čalogović. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 25 jed. | ||
| 520 | 8 | |a Summary: This paper presents results of the structural investigation on the human insulin hexamer derivative stabilised by nickel coordination. Single crystals of the Ni-insulin derivative were prepared by the hanging drop vapour diffusion crystallisation method using metal-free insulin and nickel(II) acetate tetrahydrate. The low-temperature crystal structure was determined by the single crystal X-ray crystallographic method with data extending to 1.35 Å spacing. The investigated insulin derivative exhibits the T6 form of insulin and crystallizes in the trigonal system in space group R3, with the unit cell parameters a = b = 81.41 Å and c = 33.75 Å. There are two nickel atoms per insulin hexamer and both are octahedrally coordinated by three Nε2 atoms of three symmetry-related HisB10/HisD10 and three oxygen atoms of three symmetry-related water molecules | |
| 653 | 0 | |a Inzulin |a Derivati inzulina |a Nikal |a Kristalna struktura | |
| 700 | 1 | |a Dodson, Eleanor J. | |
| 700 | 1 | |a Dodson, Guy G. | |
| 700 | 1 | |a Matković-Čalogović, Dubravka | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 82 (2009), 2 ; str. 433-438 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B02/09 | ||
| 998 | |a Luko100426 |c vol2o130430 | ||
| 856 | 4 | 2 | |u http://hrcak.srce.hr/cca |y Croatica Chemica Acta |