Synthesis, structure and cytotoxicity of platinum(IV) complexes of 3-aminocyclohexanespiro-5-hydantoin and 3-aminocycloheptanespiro-5-hydantoin

Summary: Two new platinum(IV) complexes of 3-aminocyclohexanespiro-5-hydantoin (achsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were prepared and characterized. Ab initio calculation of the structure and the measurements of IR and NMR spectra of complexes were also performed. The complexes...

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Matična publikacija: Croatica chemica acta
82 (2009), 3 ; str. 607-612
Glavni autor: Kushev, Daniel (-)
Ostali autori: Enčev, Venelin (-), Najdenova, Emilija Dimitrova, Detcheva, Roumiana, Spassovska, Nadejda, Grancharov, Konstantin
Vrsta građe: Članak
Jezik: eng
Predmet:
Online pristup: Croatica Chemica Acta
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100 1 |a Kushev, Daniel 
245 1 0 |a Synthesis, structure and cytotoxicity of platinum(IV) complexes of 3-aminocyclohexanespiro-5-hydantoin and 3-aminocycloheptanespiro-5-hydantoin /  |c Daniel Kushev, Venelin Enchev, Emilya Naydenova, Roumiana Detcheva, Nadejda Spassovska, and Konstantin Grancharov. 
300 |b Ilustr. 
504 |a Bibliografija: 24 jed 
520 8 |a Summary: Two new platinum(IV) complexes of 3-aminocyclohexanespiro-5-hydantoin (achsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were prepared and characterized. Ab initio calculation of the structure and the measurements of IR and NMR spectra of complexes were also performed. The complexes were evaluated for in vitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N. The complexes exerted low in vitro toxicity, comparable with that of the corresponding platinum(II) complexes 
653 0 |a Platina(IV)  |a Citotoksičnost  |a Molekularna struktura 
700 1 |a Enčev, Venelin 
700 1 |a Najdenova, Emilija Dimitrova 
700 1 |a Detcheva, Roumiana 
700 1 |a Spassovska, Nadejda 
700 1 |a Grancharov, Konstantin 
773 0 |t Croatica chemica acta  |x 0011-1643  |g 82 (2009), 3 ; str. 607-612  |w nsk.(HR-ZaNSK)000001621 
981 |b B02/09 
998 |a Luko100427  |c vol2o130307 
856 4 2 |u http://hrcak.srce.hr/cca  |y Croatica Chemica Acta