Synthesis of novel indane-1,3-dione derivatives and their biological evaluation as anticoagulant agents
Summary: 2-Substituted derivatives of indane-1,3-dione 3a–f , 5a–g, 6a–g were synthesized and investigated as anticoagulant agents. 2-Arylindane-1,3-diones (3) were obtained in the reaction of phthalide with appropriate arylaldehydes. 2-Arylmethyleneindane-1,3-diones (5) were prepared by condensatio...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000734869/Details |
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| Matična publikacija: |
Croatica chemica acta 82 (2009), 3 ; str. 613-618 |
| Glavni autor: | Mitka, Katarzyna (-) |
| Ostali autori: | Kowalski, Piotr (-), Pawelec, Dariusz, mikrobiolog, Majka, Zbigniew |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
Croatica Chemica Acta |
| LEADER | 01811caa a2200301 ir4500 | ||
|---|---|---|---|
| 001 | NSK01000734869 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20150921154758.0 | ||
| 007 | ta | ||
| 008 | 100427s2009 ci ||| ||eng | ||
| 035 | |9 (HR-ZaNSK)737491 | ||
| 035 | |a (HR-ZaNSK)000734869 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 042 | |a croatica | ||
| 080 | |a 54 |2 MRF 1998. | ||
| 100 | 1 | |a Mitka, Katarzyna | |
| 245 | 1 | 0 | |a Synthesis of novel indane-1,3-dione derivatives and their biological evaluation as anticoagulant agents / |c Katarzyna Mitka, Piotr Kowalski, Dariusz Pawelec, Zbigniew Majka. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 16 jed | ||
| 520 | 8 | |a Summary: 2-Substituted derivatives of indane-1,3-dione 3a–f , 5a–g, 6a–g were synthesized and investigated as anticoagulant agents. 2-Arylindane-1,3-diones (3) were obtained in the reaction of phthalide with appropriate arylaldehydes. 2-Arylmethyleneindane-1,3-diones (5) were prepared by condensation of indane-1,3-dione with the corresponding arylaldehydes. The compounds 5 were converted into their methyl analogues 6 by reduction with sodium tetrahydroborate. All of the compounds studied were screened for the anticoagulant activity. The highest prothrombin time was established for 2-[4-(methyl-sulfanyl)phenyl]indane-1,3-dione (3c) (PT = 33.71(±26.01) s), which was very close to PT of the drug anisindione (PT = 36.0(±26.42) s) | |
| 653 | 0 | |a Indan-1,3-dion |a Antikoagulacijsko djelovanje |a Protrombinsko vrijeme | |
| 700 | 1 | |a Kowalski, Piotr | |
| 700 | 1 | |a Pawelec, Dariusz, |c mikrobiolog | |
| 700 | 1 | |a Majka, Zbigniew | |
| 773 | 0 | |t Croatica chemica acta |x 0011-1643 |g 82 (2009), 3 ; str. 613-618 |w nsk.(HR-ZaNSK)000001621 | |
| 981 | |b B02/09 | ||
| 998 | |a Luko100427 |c vol2o130307 | ||
| 856 | 4 | 2 | |u http://hrcak.srce.hr/cca |y Croatica Chemica Acta |