Biochemical bone turnover markers
Summary: Osteoporosis is a systemic disease, which is characterized by reduced bone mass and microarchitectural deterioration of the bone tissue, resulting in an increased risk of fracture. Since osteoporosis is today a disease with high incidence rate, the aim of this study was to determine a corre...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01000738111/Details |
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| Matična publikacija: |
Collegium antropologicum. Supplement 33 (2009), 2 ; str. 21-24 |
| Glavni autor: | Mihaljević, Ivan, liječnik (-) |
| Ostali autori: | Mudri, Dunja (-), Smolić, Robert, Tucak-Zorić, Sandra |
| Vrsta građe: | Članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
Collegium Antropologicum |
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| 008 | 100531s2009 ci ||| ||eng | ||
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| 100 | 1 | |a Mihaljević, Ivan, |c liječnik | |
| 245 | 1 | 0 | |a Biochemical bone turnover markers : |b significance in patients with osteoporosis / |c Ivan Mihaljević, Dunja Mudri, Robert Smolić, Marina Smolić, Sandra Tucak-Zorić. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 34 jed. | ||
| 520 | 8 | |a Summary: Osteoporosis is a systemic disease, which is characterized by reduced bone mass and microarchitectural deterioration of the bone tissue, resulting in an increased risk of fracture. Since osteoporosis is today a disease with high incidence rate, the aim of this study was to determine a correlation between bone mass density (BMD) and concentration of biochemical bone turnover markers – deoxypyridinoline (DPD) as a marker of bone resorption, and osteocalcin (OC) as a marker of bone formation. The study included 70 women between 33 and 76 years of age. In all women BMD was measured by Dual X-ray Absorptiometry (DXA) as a T-score. T-score was defined as the number of standard deviations of the bone mass density from the maximum bone mass density in young adults. According to T-score, patients were divided into three groups: patients with osteoporosis, patients with osteopenia and control group consisting of patients with normal T-score. DPD in urine and OC in serum were measured by a routine procedure. Results: a negative correlation between BMD and concentration of bone turnover marker was discovered. One-way analysis of variance and Pearson correlation were used for statistical analysis, with a P value <0.05 being considered significant. Although a negative correlation was discovered, we concluded that both procedures have a significant role in diagnosis and follow-up of patients with osteoporosis | |
| 653 | 0 | |a Osteoporoza |a Koštana pregradnja |a Gustoća koštane mase |a Biokemijski biljezi |a Deoksipiridinolin |a Osteokalcin | |
| 700 | 1 | |a Mudri, Dunja | |
| 700 | 1 | |a Smolić, Robert | |
| 700 | 1 | |a Tucak-Zorić, Sandra | |
| 773 | 0 | |t Collegium antropologicum. Supplement |x 0353-3735 |g 33 (2009), 2 ; str. 21-24 |w nsk.(HR-ZaNSK)000028941 | |
| 981 | |b B04/09 | ||
| 998 | |a Luko100531 |c vol2o130416 | ||
| 856 | 4 | 2 | |u http://hrcak.srce.hr/coll-antropol |y Collegium Antropologicum |