Physicochemical properties, cytotoxicity, and antioxidative activity of natural deep eutectic solvents containing organic acid

Natural deep eutectic solvents (NADES) may be considered ‘designer solvents’ due to their numerous structural variations and the possibility of tailoring their physicochemical properties. Prior to their industrial application, characterization of NADES is essential, including determination of their...

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Matična publikacija: Chemical & biochemical engineering quarterly (Online)
33 (2019), 1 ; str. 1-18
Glavni autori: Mitar, Anamarija (Author), Panić, Manuela, Prlić Kardum, Jasna, Halambek, Jasna, Sander, Aleksandra, Zagajski Kučan, Kristina, Radojčić Redovniković, Ivana, Radošević, Kristina
Vrsta građe: e-članak
Jezik: eng
Predmet:
Online pristup: https://doi.org/10.15255/CABEQ.2018.1454
Chemical & biochemical engineering quarterly (Online)
Hrčak
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024 7 |2 doi  |a 10.15255/CABEQ.2018.1454 
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044 |a ci  |c hr 
080 1 |a 502/504  |2 2011 
080 1 |a 577  |2 2011 
100 1 |a Mitar, Anamarija  |4 aut 
245 1 0 |a Physicochemical properties, cytotoxicity, and antioxidative activity of natural deep eutectic solvents containing organic acid  |h [Elektronička građa] /  |c Anamarija Mitar, Manuela Panić, Jasna Prlić Kardum, Jasna Halambek, Aleksandra Sander, Kristina Zagajski Kučan, Ivana Radojčić Redovniković, Kristina Radošević. 
300 |b Graf. prikazi. 
504 |a Bibliografija: 54 jed. 
504 |a Summary. 
520 |a Natural deep eutectic solvents (NADES) may be considered ‘designer solvents’ due to their numerous structural variations and the possibility of tailoring their physicochemical properties. Prior to their industrial application, characterization of NADES is essential, including determination of their physicochemical properties, cytotoxicity, and antioxidative activity. The most important physicochemical properties of eight prepared NADES (choline chloride:malic acid, proline:malic acid, choline chloride:proline:malic acid, betaine:malic acid, malic acid:glucose, malic acid:glucose:glycerol, choline chloride:citric acid, and betaine:citric acid) were measured as functions of temperature and water content. In general, the structure of prepared NADES greatly influences their physical properties, which could be successfully modified and adjusted by addition of water. All tested NADES were absolutely benign and noncorrosive for investigated steel X6CrNiTi18-10. Furthermore, cytotoxicity of prepared solvents was assessed toward three human cell lines (HEK-293T, HeLa, and MCF-7 cells), and antioxidative activity was measured by the Oxygen Radical Absorbance Capacity (ORAC) method. With regard to cell viability, all tested NADES containing carboxylic acid could be classified as practically harmless and considered environmentally safe. The ORAC values indicated that the tested NADES displayed antioxidative activity. 
653 0 |a Eutektička otapala  |a Duboka eutektička otapala  |a Prirodna eutektička otapala  |a Organska kiselina  |a Fizikalno-kemijska svojstva  |a Citotoksičnost  |a Antioksidativno djelovanje  |a Stanična kultura  |a Industrijska primjena  |a Zaštita okoliša 
700 1 |a Panić, Manuela  |4 aut 
700 1 |a Prlić Kardum, Jasna  |4 aut 
700 1 |a Halambek, Jasna  |4 aut 
700 1 |a Sander, Aleksandra  |4 aut 
700 1 |a Zagajski Kučan, Kristina  |4 aut 
700 1 |a Radojčić Redovniković, Ivana  |4 aut 
700 1 |a Radošević, Kristina  |4 aut 
773 0 |t Chemical & biochemical engineering quarterly (Online)  |x 1846-5153  |g 33 (2019), 1 ; str. 1-18  |w nsk.(HR-ZaNSK)000622963 
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998 |b tino2009  |p arui2203 
856 4 0 |u https://doi.org/10.15255/CABEQ.2018.1454 
856 4 0 |u http://silverstripe.fkit.hr/cabeq/past-issues/article/1639  |y Chemical & biochemical engineering quarterly (Online) 
856 4 1 |y Digitalna.nsk.hr 
856 4 0 |u https://hrcak.srce.hr/218879  |y Hrčak