Synthesis of novel benzamide-piperazine-sulfonamide hybrids as potential anticancer agents
The synthesis of a series of substituted hippuric acid (2-benzamidoacetic acid) derivatives containing arylsulfonylpiperazine nucleus (3a–j, 4a–j) is described. The compounds were synthesized by coupling hippuric/4-fluorohippuric acid with various arylsulfonylpiperazines using N-(3-dimethylaminoprop...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001074281/Details |
|---|---|
| Matična publikacija: |
Croatica chemica acta (Online) 92 (2019), 3 ; str. 393-402 |
| Glavni autori: | Ramalingeswara Rao, B. (Author), Rao Katiki, Mohana, Kommula, Dileep, Narayanan, SaiShyam, Anto, Ruby John, Murty, M. S. R. |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.5562/cca3535 Hrčak |
| LEADER | 02529naa a22004094i 4500 | ||
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| 001 | NSK01001074281 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20220216123419.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 200916s2019 ci a |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.5562/cca3535 | |
| 035 | |a (HR-ZaNSK)001074281 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 54 |2 2011 | |
| 080 | 1 | |a 615 |2 2011 | |
| 100 | 1 | |a Ramalingeswara Rao, B. |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 0 | |a Synthesis of novel benzamide-piperazine-sulfonamide hybrids as potential anticancer agents |h [Elektronička građa] / |c B. Ramalingeswara Rao, Mohana Rao Katiki, Dileep Kommula, SaiShyam Narayanan, Ruby John Anto, M. S. R. Murty. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 34 jed. | ||
| 504 | |a Abstract. | ||
| 520 | |a The synthesis of a series of substituted hippuric acid (2-benzamidoacetic acid) derivatives containing arylsulfonylpiperazine nucleus (3a–j, 4a–j) is described. The compounds were synthesized by coupling hippuric/4-fluorohippuric acid with various arylsulfonylpiperazines using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (EDCI). The structures of all the new compounds were confirmed by IR, NMR and MS spectral data. All the synthesized compounds have been evaluated for their in vitro cytotoxicity towards five human cancer cell lines of different origins viz. HeLa (cervical), A549 (lung), A375 (skin), MD-AMB-231(breast) and T98G (brain) and their IC50 values were determined. Among the compounds tested, 3b, 3d, 3g, 4c and 4e displayed significant cytotoxic activity (IC50 = 24.2–38.2 µM). T98G was the most sensitive cell line towards the compounds studied followed by HeLa, A375, A549 and MD-AMB-231. | ||
| 653 | 0 | |a Benzamid |a Piperazin |a Sulfonamidi |a Karboksilne kiseline |a Hipurna kiselina |a Supstitucijske reakcije |a Novi lijekovi |a Protutumorsko djelovanje |a Citotoksičnost |a Stanična kultura |a In vitro istraživanje | |
| 700 | 1 | |a Rao Katiki, Mohana |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Kommula, Dileep |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Narayanan, SaiShyam |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Anto, Ruby John |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Murty, M. S. R. |4 aut |9 HR-ZaNSK | |
| 773 | 0 | |t Croatica chemica acta (Online) |x 1334-417X |g 92 (2019), 3 ; str. 393-402 |w nsk.(HR-ZaNSK)000255036 | |
| 981 | |b Be2019 |b B05/19 | ||
| 998 | |b tino2010 | ||
| 856 | 4 | 0 | |u https://doi.org/10.5562/cca3535 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/226910 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |