Screening of natural deep eutectic solvents for green synthesis of 2-methyl-3-substituted quinazolinones and microwave-assisted synthesis of 3-aryl quinazolinones in ethanol
In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of 2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Be...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001074286/Details |
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| Matična publikacija: |
Croatica chemica acta (Online) 92 (2019), 4 ; str. 511-517 |
| Glavni autori: | Komar, Mario (Author), Molnar, Maja, biotehnologinja, Konjarević, Anastazija |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.5562/cca3597 Hrčak |
| LEADER | 02567naa a22003734i 4500 | ||
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| 001 | NSK01001074286 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20230201122042.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 200916s2020 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.5562/cca3597 | |
| 035 | |a (HR-ZaNSK)001074286 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 577 |2 2011 | |
| 080 | 1 | |a 502/504 |2 2011 | |
| 100 | 1 | |a Komar, Mario |4 aut | |
| 245 | 1 | 0 | |a Screening of natural deep eutectic solvents for green synthesis of 2-methyl-3-substituted quinazolinones and microwave-assisted synthesis of 3-aryl quinazolinones in ethanol |h [Elektronička građa] / |c Mario Komar, Maja Molnar, Anastazija Konjarević. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 47 jed. | ||
| 504 | |a Summary. | ||
| 520 | |a In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of 2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Benzoxazinone, which was used as an intermediate in the synthesis of 2-methyl-3-substituted quinazolinones, was prepared conventionally from anthranilic acid and acetic anhydride. In order to find the most appropriate synthetic path, twenty natural deep eutectic solvents were applied as a solvent in these syntheses. Choline chloride:urea (1 : 2) was found to be the most efficient solvent and was further used in the synthesis of 2-methyl quinazolinone derivatives (2–12). 3-Aryl quinazolinones (13–17), on the other hand, were synthesized in one-pot microwave-assisted reaction of anthranilic acid, different amines and trimethyl orthoformate. All compounds were synthesized in good to excellent yields, characterized by LC-MS/MS spectrometry and 1H- and 13C-NMR spectroscopy. | ||
| 653 | 0 | |a Zelena tehnologija |a Eutektička otapala |a Duboka eutektička otapala |a Prirodna eutektička otapala |a Etanol |a Mikrovalna sinteza |a Kinazolin |a Kinazolinoni |a Antranilna kiselina |a Amini |a Supstitucija | |
| 700 | 1 | |a Molnar, Maja, |c biotehnologinja |4 aut | |
| 700 | 1 | |a Konjarević, Anastazija |4 aut | |
| 773 | 0 | |t Croatica chemica acta (Online) |x 1334-417X |g 92 (2019), 4 ; str. 511-517 |w nsk.(HR-ZaNSK)000255036 | |
| 981 | |b Be2020 |b B01/20 | ||
| 998 | |b dalo2011 |p arui2211 | ||
| 856 | 4 | 0 | |u https://doi.org/10.5562/cca3597 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/236327 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |