Neoangiogenesis and microvascular density in myelodysplastic syndrome
Angiogenesis has a significant part in the pathogenesis of hematological malignancies, such as leukemia and myelodysplastic syndromes (MDS). We evaluated the relationship between morphometric, morphological and clinical features of MDS. Blood vessels of 31 newly diagnosed MDS bone marrow biopsies we...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001079617/Details |
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| Matična publikacija: |
Molecular and experimental biology in medicine 2 (2019), 2 ; str. 40-50 |
| Glavni autori: | Škrtić, Anita (Author), Gredelj Šimec, Njetočka, Kardum-Skelin, Ika, Lovrić, Eva, Mužinić, Darija, Gašparov, Slavko, Ostojić Kolonić, Slobodanka |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.33602/mebm.2.2.7 Molecular and experimental biology in medicine Hrčak |
| LEADER | 02896naa a22004214i 4500 | ||
|---|---|---|---|
| 001 | NSK01001079617 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20201126163409.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 201103s2019 ci ad |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.33602/mebm.2.2.7 | |
| 035 | |a (HR-ZaNSK)001079617 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 616 |2 2011 | |
| 100 | 1 | |a Škrtić, Anita |4 aut | |
| 245 | 1 | 0 | |a Neoangiogenesis and microvascular density in myelodysplastic syndrome |h [Elektronička građa] : |b a single center experience / |c Anita Skrtic, Njetocka Gredelj-Simec, Ika Kardum-Skelin, Eva Lovric, Darija Muzinic, Slavko Gasparov, Slobodanka Ostojic Kolonic. |
| 300 | |b Ilustr. ; graf. prikazi. | ||
| 504 | |a Bibliografija: 46 jed. | ||
| 504 | |a Abstract. | ||
| 520 | |a Angiogenesis has a significant part in the pathogenesis of hematological malignancies, such as leukemia and myelodysplastic syndromes (MDS). We evaluated the relationship between morphometric, morphological and clinical features of MDS. Blood vessels of 31 newly diagnosed MDS bone marrow biopsies were immunohistochemically analyzed using CD34 and compared with 8 controls and 13 chronic myelomonocytic leukemias (CMML). MDS were categorized into three risk groups: low-, intermediate- and high-risk MDS. Microvascular density (MVD) and major and minor axis length were analyzed using digital image analysis. Overall, MDS had significantly higher MVD and lower minor axis values than the control group and CMML. High-risk MDS had significantly higher MVD compared to the controls, while all MDS risk groups had lower minor axis values than the control group. Increased minor and major axis values were prognostic predictors of shorter overall survival in all MDS risk groups and CMML patients. In conclusion, angiogenesis presents one of the essential factors in MDS pathogenesis and progression characterized by descriptive marrow microvascular network transformation. The size-related features are powerful indicators of survival in MDS patients. | ||
| 653 | 0 | |a Mijelodisplastični sindrom |a Mikrovaskularna gustoća |a Neoangiogeneza |a Maligne bolesti | |
| 700 | 1 | |a Gredelj Šimec, Njetočka |4 aut | |
| 700 | 1 | |a Kardum-Skelin, Ika |4 aut | |
| 700 | 1 | |a Lovrić, Eva |4 aut | |
| 700 | 1 | |a Mužinić, Darija |4 aut | |
| 700 | 1 | |a Gašparov, Slavko |4 aut | |
| 700 | 1 | |a Ostojić Kolonić, Slobodanka |4 aut | |
| 773 | 0 | |t Molecular and experimental biology in medicine |x 2584-671X |g 2 (2019), 2 ; str. 40-50 |w nsk.(HR-ZaNSK)000985906 | |
| 981 | |b Be2019 |b B05/19 | ||
| 998 | |b tino2011 | ||
| 856 | 4 | 0 | |u https://doi.org/10.33602/mebm.2.2.7 |
| 856 | 4 | 0 | |u http://mebm.eu/index.php/journal/article/view/60 |y Molecular and experimental biology in medicine |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/226237 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |