LINE-1 DNA methylation and congenital heart defects in Down syndrome
DNA methylation is a key epigenetic mechanism that plays a significant role in regulating gene activity during cardiac development. Congenital heart defects (CHD) are one of the most common abnormalities occurring in 40% -60% of cases with Down syndrome (DS). The main aim of this study was to establ...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001079629/Details |
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| Matična publikacija: |
Molecular and experimental biology in medicine 2 (2019), 1 ; str. 34-37 |
| Glavni autori: | Vraneković, Jadranka (Author), Babić Božović, Ivana, Zivkovic, Maja, Stankovic, Aleksandra, Brajenović-Milić, Bojana |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.33602/mebm.2.1.6 Molecular and experimental biology in medicine Hrčak |
| LEADER | 02850naa a22004214i 4500 | ||
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| 001 | NSK01001079629 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20201125122946.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 201103s2019 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.33602/mebm.2.1.6 | |
| 035 | |a (HR-ZaNSK)001079629 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 575 |2 2011 | |
| 080 | 1 | |a 616 |2 2011 | |
| 100 | 1 | |a Vraneković, Jadranka |4 aut | |
| 245 | 1 | 0 | |a LINE-1 DNA methylation and congenital heart defects in Down syndrome |h [Elektronička građa] / |c Jadranka Vranekovic, Ivana Babic Bozovic, Maja Zivkovic, Aleksandra Stankovic, Bojana Brajenovic Milic. |
| 246 | 3 | |a Long interspersed nucleotide element-1 DNA | |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 37 jed. | ||
| 504 | |a Abstract. | ||
| 520 | |a DNA methylation is a key epigenetic mechanism that plays a significant role in regulating gene activity during cardiac development. Congenital heart defects (CHD) are one of the most common abnormalities occurring in 40% -60% of cases with Down syndrome (DS). The main aim of this study was to establish the association of long interspersed nucleotide element-1 (LINE-1) DNA methylation in children with DS and the presence of CHD. The LINE-1 DNA methylation was investigated in peripheral blood lymphocytes on a sample of 42 people with DS by quantification of LINE-1 methylation using the MethyLight method. No significant differences in global DNA methylation were found according to the presence of CHD (P=1.000), but values of LINE-1 DNA methylation were significantly influenced by gender (R2=19.1%; P=0.025). Significant probability of 19.1% was found in women with DS who had lower LINE-1 DNA methylation values than DS male . Gender was a statistically significant predictor of LINE-1 DNA methylation, although the difference was not statistically significant, female subjects had lower LINE-1 DNA methylation values (P=0.068). Further research will clarify the role of lower LINE-1 DNA methylation in the formation of CHD among DS females. | ||
| 653 | 0 | |a Kongenitalne srčane mane |a Downov sindrom |a LINE-1 |a Metilacija molekule DNK | |
| 700 | 1 | |a Babić Božović, Ivana |4 aut | |
| 700 | 1 | |a Zivkovic, Maja |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Stankovic, Aleksandra |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Brajenović-Milić, Bojana |4 aut | |
| 773 | 0 | |t Molecular and experimental biology in medicine |x 2584-671X |g 2 (2019), 1 ; str. 34-37 |w nsk.(HR-ZaNSK)000985906 | |
| 981 | |b Be2019 |b B05/19 | ||
| 998 | |b tino2011 | ||
| 856 | 4 | 0 | |u https://doi.org/10.33602/mebm.2.1.6 |
| 856 | 4 | 0 | |u http://mebm.eu/index.php/journal/article/view/46 |y Molecular and experimental biology in medicine |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/224342 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |