Hypoadrenocorticism in dogs - the Mad Hatter of veterinary internal medicine
Hypoadrenocorticism arises from insufficient adrenal gland function and is also known as Addison’s disease, a rarely occurring disease (0.1%) in dogs. Due to its oscillatory course and overall nonspecific symptoms, it is a diagnostic challenge for clinicians, and is often misdiagnosed or unattended...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001084154/Details |
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| Matična publikacija: |
Veterinarska stanica (Online) 51 (2020), 3 ; str. 281-292 |
| Glavni autori: | Palić, Magdalena (Author), Brkljačić, Mirna, Kiš, Ivana, veterinarka, Crnogaj, Martina, Kučer, Nada, Torti, Marin, Šmit, Iva, Kajin, Filip, Matijatko, Vesna |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.46419/vs.51.3.5 Hrčak |
| LEADER | 04997naa a22004454i 4500 | ||
|---|---|---|---|
| 001 | NSK01001084154 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20210112132340.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 201210s2020 ci ad |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.46419/vs.51.3.5 | |
| 035 | |a (HR-ZaNSK)001084154 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 636.09 |2 2011 | |
| 100 | 1 | |a Palić, Magdalena |4 aut | |
| 245 | 1 | 0 | |a Hypoadrenocorticism in dogs - the Mad Hatter of veterinary internal medicine |h [Elektronička građa] / |c Magdalena Palić, Mirna Brkljačić, Ivana Kiš, Martina Crnogaj, Nada Kučer, Marin Torti, Iva Šmit, Filip Kajin, Vesna Matijatko. |
| 300 | |b Ilustr., graf. prikazi. | ||
| 504 | |a Bibliografija: 30 jed. | ||
| 504 | |a Summary ; Sažetak. | ||
| 520 | |a Hypoadrenocorticism arises from insufficient adrenal gland function and is also known as Addison’s disease, a rarely occurring disease (0.1%) in dogs. Due to its oscillatory course and overall nonspecific symptoms, it is a diagnostic challenge for clinicians, and is often misdiagnosed or unattended among other differentials. There are two forms of hypoadrenocorticism: primary and secondary. The aim of this study was to analyse the data of dogs suffering from Addison’s disease, treated at the Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Croatia and to compare them with data from similar institutions worldwide. The archive of Clinic for Internal Medicine, Faculty of Veterinary Medicine, Zagreb, Croatia was searched to investigate and statistically analyse signalment, clinical and laboratory data, and the duration of symptoms, treatment protocols and outcome of canine hypoadrenocorticism. The study group included 14 dogs (36% male and 64% female) diagnosed with hypoadrenocorticism. All dogs had a history of gastrointestinal symptoms, i.e. vomiting in 100%, diarrhoea in 64% and melena in 7%. Hypovolemic shock was noted in 57%, hypothermia in 64% and bradycardia in 29% of cases. The most frequently observed laboratory abnormalities were an increase in BUN (86%), creatinine (57%) and potassium concentration (79%), and a decrease in sodium (71%), Na/K ratio (86%), cholesterol (21%) and glucose concentration (21%). Duration of symptoms (till ACTH stimulation test performance) was broad, from 2 – 2190 days (median 90±1195.5 days). The outcome was favourable in 100% cases after initiation of adequate treatment. | ||
| 520 | |a Pod pojmom hipoadrenokorticizam podrazumijevamo smanjenu funkciju nadbubrežne žlijezde, a sama bolest je poznata i pod nazivom Addisonova bolest. Hipoadrenorticizam je bolest koja se u pasa rijetko javlja s učestalošću od oko 0,1 %. Zbog kombinacije nespecifičnih simptoma i njihova osciliranja predstavlja dijagnostički izazov te se smatra bolešću čija se u veterinarskoj medicini dijagnoza najčešće previdi. Postoji primarni i sekundarni oblik bolesti. Cilj je ovog istraživanja bio detaljno analizirati podatke pasa s Addisonovom bolešću zaprimljenih u Kliniku za unutarnje bolesti Veterinarskog fakulteta Sveučilišta u Zagrebu te ih usporediti s podatcima iz sličnih institucija u svijetu. Detaljno su pretraženi podatci arhive klinike, a analizirani su i statistički obrađeni klinički i laboratorijski parametri, vrijeme trajanja simptoma te terapijski protokoli i ishod u pasa s hipoadrenokorticizmom. Istraživanu skupinu činilo je 14 pasa s hipoadrenokorticizmom od kojih 36 % mužjaka i 64 % ženki. U svih pasa zabilježeni su recidivirajući simptomi od strane probavnog sustava, od kojih se u 100 % slučajeva javljalo povraćanje, u 64 % proljev, a u 7 % melena. Klinički je u 57 % pasa uočen hipovolemični šok, u 64 % pasa hipotermija, a u 29 % bradikardija. Od laboratorijskih pretraga najčešća odstupanja bila su povećanje koncentracije ureje (86 %), kreatinina (57 %), hiperkalemija (79 %), hiponatremija (71 %), smanjeni Na/K omjer (86 %), hipoholesterolemija (21 %) te hipoglikemija (21 %). Trajanje simptoma do provedbe ACTH-stimulacijskog testa iznosilo je 2 - 2190 dana (prosječno 90±1195 dana), a nakon uvođenja adekvatne terapije ishod je u svih pasa bio povoljan. | ||
| 653 | 0 | |a Psi |a Addisonova bolest |a Nadbubrežna žlijezda |a Hipoadrenokorticizam |a Mineralokortikoidi |a Glukokortikoidi | |
| 700 | 1 | |a Brkljačić, Mirna |4 aut | |
| 700 | 1 | |a Kiš, Ivana, |c veterinarka |4 aut | |
| 700 | 1 | |a Crnogaj, Martina |4 aut | |
| 700 | 1 | |a Kučer, Nada |4 aut | |
| 700 | 1 | |a Torti, Marin |4 aut | |
| 700 | 1 | |a Šmit, Iva |4 aut | |
| 700 | 1 | |a Kajin, Filip |4 aut | |
| 700 | 1 | |a Matijatko, Vesna |4 aut | |
| 773 | 0 | |t Veterinarska stanica (Online) |x 1849-1170 |g 51 (2020), 3 ; str. 281-292 |w nsk.(HR-ZaNSK)000855872 | |
| 981 | |b Be2020 |b B01/20 | ||
| 998 | |b dalo2101 | ||
| 856 | 4 | 0 | |u https://doi.org/10.46419/vs.51.3.5 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/237807 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |