The top-down approach to measurement uncertainty
Introduction: By quantifying the measurement uncertainty (MU), both the laboratory and the physician can have an objective estimate of the results’ quality. There is significant flexibility on how to determine the MU in laboratory medicine and different approaches have been proposed by Nordtest, Eur...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001102486/Details |
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| Matična publikacija: |
Biochemia medica (Online) 30 (2020), 2 ; str. 187-195 |
| Glavni autori: | Martinello, Flávia (Author), Snoj, Nada, Skitek, Milan, Jerin, Aleš |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.11613/BM.2020.020101 Biochemia medica (Online) Hrčak |
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| 008 | 210527s2020 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.11613/BM.2020.020101 | |
| 035 | |a (HR-ZaNSK)001102486 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 61 |2 2011 | |
| 080 | 1 | |a 577 |2 2011 | |
| 100 | 1 | |a Martinello, Flávia |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 4 | |a The top-down approach to measurement uncertainty |h [Elektronička građa] : |b which formula should we use in laboratory medicine? / |c Flávia Martinello, Nada Snoj, Milan Skitek, Aleš Jerin. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 28 jed. | ||
| 504 | |a Summary. | ||
| 520 | |a Introduction: By quantifying the measurement uncertainty (MU), both the laboratory and the physician can have an objective estimate of the results’ quality. There is significant flexibility on how to determine the MU in laboratory medicine and different approaches have been proposed by Nordtest, Eurolab and Cofrac to obtain the data and apply them in formulas. The purpose of this study is to compare three different top-down approaches for the estimation of the MU and to suggest which of these approaches could be the most suitable choice for routine use in clinical laboratories. Materials and methods: Imprecision and bias of the methods were considered as components of the MU. The bias was obtained from certified reference calibrators (CRC), proficiency tests (PT), and inter-laboratory internal quality control scheme (IQCS) programs. The bias uncertainty, the combined and the expanded uncertainty were estimated using the Nordtest, Eurolab and Cofrac approaches. Results: Using different approaches, the expanded uncertainty estimates ranged from 18.9-40.4%, 18.2-22.8%, 9.3-20.9%, and 7.1-18.6% for cancer antigen (CA) 19-9, testosterone, alkaline phosphatase (ALP), and creatinine, respectively. Permissible values for MU and total error ranged from 16.0-46.1%, 13.1-21.6%, 10.7-26.2%, and 7.5-17.3%, respectively. Conclusion: The bias was highest using PT, followed by CRC and IQCS data, which were similar. The Cofrac approach showed the highest uncertainties, followed by Eurolab and Nordtest. However, the Eurolab approach requires additional measurements to obtain uncertainty data. In summary, the Nordtest approach using IQCS data was therefore found to be the most practical formula. | ||
| 653 | 0 | |a Laboratorijska medicina |a Mjerna nesigurnost |a Kontrola kvalitete |a Pogreška mjerenja | |
| 700 | 1 | |a Snoj, Nada |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Skitek, Milan |4 aut | |
| 700 | 1 | |a Jerin, Aleš |4 aut | |
| 773 | 0 | |t Biochemia medica (Online) |x 1846-7482 |g 30 (2020), 2 ; str. 187-195 |w nsk.(HR-ZaNSK)000655372 | |
| 981 | |b Be2020 |b B03/20 | ||
| 998 | |b dalo2107 | ||
| 856 | 4 | 0 | |u https://doi.org/10.11613/BM.2020.020101 |
| 856 | 4 | 0 | |u https://www.biochemia-medica.com/en/journal/30/2/10.11613/BM.2020.020101 |y Biochemia medica (Online) |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/238900 |y Hrčak |