Dabigatran use associated with hemopericardium and hemothorax
Concurrent spontaneous hemopericardium and hemothorax due to anticoagulant use are extremely rare in clinical practice. Dabigatran is an oral direct thrombin inhibitor approved to prevent stroke or thromboembolic episodes in patients with nonvalvular atrial fibrillation. We report the case of a 73-y...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001104465/Details |
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| Matična publikacija: |
Collegium antropologicum (Online) 44 (2020), 3 ; str. 155-158 |
| Glavni autori: | Katić, Josip, liječnik (Author), Skelin, Marko, Katić, Ana, studentica medicine, Katić, Karla, Perković-Avelini, Ružica, Rahelić, Dario, Mirat, Jure |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.5671/ca.44.3.7 Hrčak Collegium antropologicum (Online) |
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| 024 | 7 | |2 doi |a 10.5671/ca.44.3.7 | |
| 035 | |a (HR-ZaNSK)001104465 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng |b hrv | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 615 |2 2011 | |
| 100 | 1 | |a Katić, Josip, |c liječnik |4 aut | |
| 245 | 1 | 0 | |a Dabigatran use associated with hemopericardium and hemothorax |h [Elektronička građa] / |c Josip Katić, Marko Skelin, Ana Katić, Karla Katić, Ružica Avelini Perković, Dario Rahelić, Jure Mirat. |
| 504 | |a Bibliografske bilješke na kraju teksta. | ||
| 504 | |a Abstract ; Sažetak. | ||
| 520 | |a Concurrent spontaneous hemopericardium and hemothorax due to anticoagulant use are extremely rare in clinical practice. Dabigatran is an oral direct thrombin inhibitor approved to prevent stroke or thromboembolic episodes in patients with nonvalvular atrial fibrillation. We report the case of a 73-year-old man who received dabigatran therapy (150 mg twice a day) for 3 months and developed massive spontaneous hemothorax and hemopericardium associated with fever. Emergency chest computed tomography scan established higher-density pericardial effusion (22HU) and left pleural effusion of heterogeneous density (5–15 HU) which could be hemorrhagic content while the heart ultrasound finding confirmed pericardial effusion 7–9 mm thick, without affecting hemodynamics. Almost 1100 mL of blood was drained by ultrasoundguided thoracentesis. After excluding other possible causes, diagnostic withdrawal was performed for dabigatran and no further pleural or pericardium effusion developed after dabigatran was discontinued. Therefore, practitioners could be aware of hemothorax as well as hemopericardium as a potential complication of dabigatran therapy. | ||
| 520 | |a Istodobno spontani hemoperikard i hemotoraks tijekom primjene oralnih antikoagulanata izuzetno je rijetka pojava u kliničkoj praksi. Dabigatran je oralni izravni inhibitor trombina odobren za prevenciju moždanog udara ili tromboembolijskih događaja u bolesnika s nevalvularnom fibrilacijom atrija. Prikazan je slučaj 73-godišnjaka na terapiji dabigatranom (150 mg dva puta dnevno) od 3 mjeseca sa razvojem masivnog spontanog hemotoraksa i hemoperikarda praćeno vrućicom. Višeslojna kompjutorizirana tomografija (MSCT) toraksa je pokazala perikardijalni izljev veće gustoće (22HU) kao lijevi pleuralni izljev heterogene gustoće (5–15 HU), opisano kao mogući hemoragični sadržaj, dok je nalaz ultrazvuka srca verificirao perikardijalni izljev od 7–9 mm, bez utjecaja na hemodinamiku. Torakocentezom se evakuira gotovo 1100 ml krvi. Urađenom kliničkom obradom isključeni su drugi uzroci te se izostavljanjem dabigatrana iz terapije prekinulo daljnje nakupljanje krvi u perikard ili pleuralni prostor. Tijekom primjene dabigatrana moguć je potencijalni nastanak hemoragičnih komplikacija na koje svakako treba pomišljati. | ||
| 653 | 0 | |a Antikoagulanti |a Dabigatran |a Fibrilacija atrija | |
| 653 | 6 | |a Prikaz slučaja | |
| 700 | 1 | |a Skelin, Marko |4 aut | |
| 700 | 1 | |a Katić, Ana, |c studentica medicine |4 aut | |
| 700 | 1 | |a Katić, Karla |4 aut | |
| 700 | 1 | |a Perković-Avelini, Ružica |4 aut | |
| 700 | 1 | |a Rahelić, Dario |4 aut | |
| 700 | 1 | |a Mirat, Jure |4 aut | |
| 773 | 0 | |t Collegium antropologicum (Online) |x 1848-9486 |g 44 (2020), 3 ; str. 155-158 |w nsk.(HR-ZaNSK)000842419 | |
| 981 | |b Be2020 |b B03/20 | ||
| 998 | |b tino2107 | ||
| 856 | 4 | 0 | |u https://doi.org/10.5671/ca.44.3.7 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/247634 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |
| 856 | 4 | 0 | |u https://www.collantropol.hr/antropo/article/view/1810 |y Collegium antropologicum (Online) |