Influence of caffeine on crystallization and amelioration of oxidative stress on in vitro model of urolithiasis
Urolithiasis is a disease characterized by formation of solid crystals within the urinary tract. Kidney stone formation is still not clear but it is mostly composed of calcium oxalate which can produce free radicals that are toxic to renal tubular cells. Oxidative stress is an important contributory...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001104470/Details |
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| Matična publikacija: |
Collegium antropologicum (Online) 44 (2020), 3 ; str. 121-125 |
| Glavni autori: | Ninčević, Vjera (Author), Kizivat, Tomislav, Omanović Kolarić, Tea, Kuna, Lucija, Cindrić, Anita, magistra medicinsko laboratorijske dijagnostike, Banovac, Anamarija, Bilić-Ćurčić, Ines, Tucak-Zorić, Sandra, Smolić, Martina |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.5671/ca.44.3.2 Hrčak Collegium antropologicum (Online) |
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| 001 | NSK01001104470 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20210706155510.0 | ||
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| 008 | 210616s2020 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.5671/ca.44.3.2 | |
| 035 | |a (HR-ZaNSK)001104470 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng |b hrv | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 616 |2 2011 | |
| 100 | 1 | |a Ninčević, Vjera |4 aut | |
| 245 | 1 | 0 | |a Influence of caffeine on crystallization and amelioration of oxidative stress on in vitro model of urolithiasis |h [Elektronička građa] / |c Vjera Ninčević, Tomislav Kizivat, Tea Omanović Kolarić, Lucija Kuna, Anita Cindrić, Anamarija Banovac, Ines Bilić Ćurčić, Sandra Tucak-Zorić, Martina Smolić. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografske bilješke na kraju teksta. | ||
| 504 | |a Abstract ; Sažetak. | ||
| 520 | |a Urolithiasis is a disease characterized by formation of solid crystals within the urinary tract. Kidney stone formation is still not clear but it is mostly composed of calcium oxalate which can produce free radicals that are toxic to renal tubular cells. Oxidative stress is an important contributory mechanism in cell damage and is associated with a number of disorders. Several studies have shown antioxidative effects of caffeine, proposing its possible role in stopping the formation of calcium oxalate stones in urinary tract. Hence, the aim of this study was to evaluate the toxic effects of calcium oxalate monohydrate crystals (COM) on renal epithelial cell line; Madin-Darby canine kidney cells subtype I (MDCK I) and Epithelial-like pig kidney cell line (LLC-PK1), and to determine possible inhibition of COM that caused oxidative stress by antioxidant treatment with caffeine in different concentrations in a cell culture model of urolithiasis. | ||
| 520 | |a Urolitijaza je bolest koju karakterizira stvaranje čvrstih kristala unutar mokraćnoga sustava. Mehanizam stvaranja bubrežnih kamenaca još je uvijek nejasan, a uglavnom se sastoji od kalcijevoga oksalata koji može proizvesti slobodne radikale toksične za bubrežne tubularne stanice. Oksidativni stres važan je mehanizam koji doprinosi oštećenju stanica i povezan je s nizom poremećaja. Nekoliko je studija pokazalo antioksidativne učinke kofeina, sugerirajući njegovu moguću ulogu u zaustavljanju stvaranja kalcijevih oksalatnih kamenaca u mokraćnim putovima. Stoga je cilj ovoga istraživanja bio procijeniti toksični učinak kristala kalcijevog oksalata monohidrata (COM) na staničnu liniju bubrežnoga epitela, Madin-Darbyjeve pseće stanice bubrega podtipa I (MDCK I) i epitelne stanice bubrega svinje (LLC-PK1), te utvrditi moguće inhibicije COM-a (uzroka oksidativnoga stresa) antioksidativnim tretmanom kofeinom u različitim koncentracijama na modelu stanične kulture urolitijaze. | ||
| 653 | 0 | |a Urolitijaza |a Oksidativni stres |a Kofein |a Kalcijev oksalat monohidrat | |
| 700 | 1 | |a Kizivat, Tomislav |4 aut | |
| 700 | 1 | |a Omanović Kolarić, Tea |4 aut | |
| 700 | 1 | |a Kuna, Lucija |4 aut | |
| 700 | 1 | |a Cindrić, Anita, |c magistra medicinsko laboratorijske dijagnostike |4 aut | |
| 700 | 1 | |a Banovac, Anamarija |4 aut | |
| 700 | 1 | |a Bilić-Ćurčić, Ines |4 aut | |
| 700 | 1 | |a Tucak-Zorić, Sandra |4 aut | |
| 700 | 1 | |a Smolić, Martina |4 aut | |
| 773 | 0 | |t Collegium antropologicum (Online) |x 1848-9486 |g 44 (2020), 3 ; str. 121-125 |w nsk.(HR-ZaNSK)000842419 | |
| 981 | |b Be2020 |b B03/20 | ||
| 998 | |b tino2107 | ||
| 856 | 4 | 0 | |u https://doi.org/10.5671/ca.44.3.2 |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/247630 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |
| 856 | 4 | 0 | |u https://www.collantropol.hr/antropo/article/view/1806 |y Collegium antropologicum (Online) |