Long-term survival of the transplanted kidney and the clinical relevance of donor-specific antibodies
The aim of our study was to evaluate the relevance of donor-specific antibodies (DSA) as defined by solid-phase single-antigen (SA) assays for predicting long-term graft survival after kidney transplantation. Sera from 132 kidney transplant recipients were retrospectively tested before, 3, 6 and 12...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001122408/Details |
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| Matična publikacija: |
Molecular and experimental biology in medicine 3 (2020), 1 ; str. 17-22 |
| Glavni autori: | Svobodova, Eva (Author), Slavcev, Antonij, Slatinska, Janka, Valhova, Sarka, Honsova, Eva, Skibova, Jelena, Striz, Ilja, Viklicky, Ondrej |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.33602/mebm.3.1.3 Molecular and experimental biology in medicine Hrčak |
| LEADER | 03124naa a22004454i 4500 | ||
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| 001 | NSK01001122408 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20220202170646.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 211228s2020 ci d |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.33602/mebm.3.1.3 | |
| 035 | |a (HR-ZaNSK)001122408 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 575 |2 2011 | |
| 080 | 1 | |a 617 |2 2011 | |
| 100 | 1 | |a Svobodova, Eva |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 0 | |a Long-term survival of the transplanted kidney and the clinical relevance of donor-specific antibodies |h [Elektronička građa] / |c Eva Svobodova, Antonij Slavcev, Janka Slatinska, Sarka Valhova, Eva Honsova, Jelena Skibova, Ilja Striz, Ondrej Viklicky. |
| 300 | |b Graf. prikazi. | ||
| 504 | |a Bibliografija: 23 jed. | ||
| 504 | |a Abstract. | ||
| 520 | |a The aim of our study was to evaluate the relevance of donor-specific antibodies (DSA) as defined by solid-phase single-antigen (SA) assays for predicting long-term graft survival after kidney transplantation. Sera from 132 kidney transplant recipients were retrospectively tested before, 3, 6 and 12 months after transplantation. The incidence of rejection and graft survival was followed up for 7 years. We found 29 episodes of acute cellular rejection (CR), 21 cases of antibody-mediated rejection (AMR) and 18 graft failures due to immunological reasons. Pre-transplant DSA and DSA three months after transplantation correlated with an increased rate of AMR and impaired graft function. After the fourth year, recipients with persistent DSA were at a higher risk of graft failure (p = 0.0317). Antibody specificity was prevailingly to HLA class I antigens (66.6% DSA, 75% non-DSA). During the first year after transplantation, the number of patients with non-DSA decreased (30.3% to 10.7%), while, due to de novo production of antibodies, the number of DSA positive patients remained constant. Conclusion: Detection of antibodies to HLA antigens using solid-phase assays, especially single-antigen bead technology before and three months after transplantation is predictive for increased incidence of antibody-mediated rejection and impaired long-term kidney graft survival. | ||
| 653 | 0 | |a Transplantacija bubrega |a Donor specifična antitijela |a Odbacivanje presatka |a HLA-antigeni | |
| 700 | 1 | |a Slavcev, Antonij |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Slatinska, Janka |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Valhova, Sarka |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Honsova, Eva |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Skibova, Jelena |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Striz, Ilja |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Viklicky, Ondrej |4 aut |9 HR-ZaNSK | |
| 773 | 0 | |t Molecular and experimental biology in medicine |x 2584-671X |g 3 (2020), 1 ; str. 17-22 |w nsk.(HR-ZaNSK)000985906 | |
| 981 | |b Be2020 |b B04/20 | ||
| 998 | |b tino2202 | ||
| 856 | 4 | 0 | |u https://doi.org/10.33602/mebm.3.1.3 |
| 856 | 4 | 0 | |u http://www.mebm.eu/index.php/journal/article/view/69 |y Molecular and experimental biology in medicine |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/238477 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |