Iatrogenic chlorpromazine abuse in a kitten
Chlorpromazine is a sedative effective phenothiazine derivative used to prevent nausea and vomiting, especially in cases of motion sickness in cats. It has serious side effects at high doses, including weakness, tremors, loss of anal sphincter tone and reflexes, hypotension, heart rhythm abnormaliti...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001145249/Details |
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| Matična publikacija: |
Veterinarska stanica (Online) 52 (2021), 3 ; str. 339-344 |
| Glavni autori: | Gülersoy, Erdem (Author), Akgün, Mehmet Umut, Erol, Büşra Burcu, Maden, Mehmet |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Predmet: | |
| Online pristup: |
https://doi.org/10.46419/vs.52.3.2 Hrčak |
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| 024 | 7 | |2 doi |a 10.46419/vs.52.3.2 | |
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| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng |b hrv | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |a 636.09 |2 2011 | |
| 100 | 1 | |a Gülersoy, Erdem |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 0 | |a Iatrogenic chlorpromazine abuse in a kitten |h [Elektronička građa] / |c Erdem Gülersoy, Mehmet Umut Akgün, Büşra Burcu Erol, Mehmet Maden. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: 15 jed. | ||
| 504 | |a Abstract ; Sažetak. | ||
| 520 | |a Chlorpromazine is a sedative effective phenothiazine derivative used to prevent nausea and vomiting, especially in cases of motion sickness in cats. It has serious side effects at high doses, including weakness, tremors, loss of anal sphincter tone and reflexes, hypotension, heart rhythm abnormalities, coma, agitation and seizures. In this case report, chlorpromazine toxicity was defined in a 4-month-old, 1.2 kg male Van kitten brought to Selcuk University Veterinary Faculty Emergency Clinic with complaints of stagnation, tremors, vomiting and excessive sleepiness. Hypothermia (35.2 °C), hyperpnea (88 breaths/min), hypersalivation, constipation, excessive agitation, tremors and incoordination were determined in the clinical examination of the kitten. It was learned from the anamnesis that 100 mg chlorpromazine was given orally before the trip against motion sickness. Electrocardiographic examination determined sinus tachycardia (220 beats/min), increase in P wave amplitude, elevation in ST complex and hypotension (S/MAP/D = 148/124/112). The major laboratory findings were metabolic acidosis (pH 7.278), hypoglycaemia (61 mg/dL), leukocytosis (22.43 m/mm3), increase in blood ured nitrogen (17.7 mg/dL), creatinine (0.6 mg/dL) and ALP (121 U/L) concentrations and hypertriglyceridemia (122 mg/dL). Based on the anamnesis, clinical, laboratory and ECG findings, the kitten was diagnosed with overdose chlorpromazine toxicity and hospitalized, and put under surveillance for continuous cardiac monitoring. Lactated ringer solution, norepinephrine tartrate, furosemide, activated charcoal and oxygen therapy were given. The treatment was successful. In conclusion, it was evaluated that continuous cardiac monitoring and controlling hypotension were important in the management of chlorpromazine toxicity, and fluid therapy, norepinephrine, diuretic and activated charcoal administrations achieve success in treatment. | ||
| 520 | |a Klorpromazin je derivat fenotiazina sa sedativnim učinkom, a rabi se za sprječavanje mučnine i povraćanja, posebice u slučajevima bolesti kretanja u mačaka. Pri velikim dozama ima ozbiljne nuspojave poput slabosti, drhtanja, gubitka tonusa analnog sfinktera i refleksa, hipotenzije, abnormalnosti srčanog ritma, kome, uznemirenosti i napadaja. U ovoj analizi slučaja, u četveromjesečnog mačića turske pasmine van težine 1,2 kg koji je doveden na hitnu pomoć Veterinarskog fakulteta Selcuk Sveučilišta s primjećenim simptomima stagnacije, drhtanja, povraćanja i prekomjerne pospanosti otkriveno je trovanje klorpromazinom. Kliničkim pregledom mačke utvrđena je hipotermija (35,2 °C), hiperpneja (88 udisaja/min), hipersalivacija, konstipacija, prekomjerna uznemirenost, drhtanje i nekoordinacija. Iz anamneze je otkriveno da je mačić prije puta oralno primio 100 mg klorpromazina, za sprječavanje bolesti kretanja. Na elektrokardiografskom pregledu ustvrđena je sinusna tahikardija (220 otkucaja/min), povećanje amplitude P vala, podizanje ST segmenta i hipotenzija (S/MAP/D = 148/124/112). Glavni laboratorijski nalazi bili su metabolička acidoza (pH 7,278), hipoglikemija (61 mg/dL), leukocitoza (22,43 m/mm3), povećanje koncentracije ureje u krvi (17,7 mg/dL), kreatinina (0,6 mg/dL) i ALP (121 U/L) i hipertrigliceridemija (122 mg/dL). Prema anamnezi, kliničkim, laboratorijskim i EKG nalazima, mačiću je dijagnosticirano trovanje prekomjernom dozom klorpromazina te je hospitaliziran, uz kontinuirano praćenje rada srca. Mačić je primao Ringerov laktat, norepinefrin tartrat, furosemid, aktivni ugljen i terapiju kisikom. Liječenje je bilo uspješno. Zaključno, procijenjeno je da su kontinuirano praćenje rada srca i kontrola hipotenzije bile važne u liječenju trovanja klorpromazinom te da tekuća terapija, norepinefrin, diuretik i aktivni ugljen postižu uspjeh u liječenju. | ||
| 653 | 0 | |a Mačke |a Sedativi |a Trovanje |a Bolest kretanja | |
| 700 | 1 | |a Akgün, Mehmet Umut |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Erol, Büşra Burcu |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Maden, Mehmet |4 aut | |
| 773 | 0 | |t Veterinarska stanica (Online) |x 1849-1170 |g 52 (2021), 3 ; str. 339-344 |w nsk.(HR-ZaNSK)000855872 | |
| 981 | |b Be2020 |b B06/20 | ||
| 998 | |b tino2211 | ||
| 856 | 4 | 0 | |u https://doi.org/10.46419/vs.52.3.2 |
| 856 | 4 | 0 | |u http://hrcak.srce.hr/241131 |y Hrčak |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |