Seroprevalence of SARS-CoV-2 infection among children in Children"s Hospital Zagreb during the initial and second wave of COVID-19 pandemic in Croatia
The study aimed to investigate the prevalence and titres of anti-SARS-CoV-2 antibodies in children treated at the Children"s Hospital Zagreb in the first and the second wave of the COVID-19 pandemic. Statistical significance of difference at two time points was done to determine how restrictive...
| Permalink: | http://skupni.nsk.hr/Record/nsk.NSK01001163329/Details |
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| Matična publikacija: |
Biochemia medica (Online) 31 (2021), 2 ; str. 283-294 |
| Glavni autori: | Lenicek Krleza, Jasna (Author), Zrinski Topic, Renata, Stevanovic, Vladimir, Lukic-Grlic, Amarela, Tabain, Irena, Misak, Zrinjka, Roic, Goran, Kaic, Bernard, Mayer, Dijana, Hruskar, Zeljka, Barbic, Ljubo, Vilibic-Cavlek, Tatjana |
| Vrsta građe: | e-članak |
| Jezik: | eng |
| Online pristup: |
https://doi.org/10.11613/BM.2021.020706 Elektronička verzija članka Elektronička verzija članka Elektronička verzija članka |
| LEADER | 03789naa a22004694i 4500 | ||
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| 001 | NSK01001163329 | ||
| 003 | HR-ZaNSK | ||
| 005 | 20230213141927.0 | ||
| 006 | m d | ||
| 007 | cr|||||||||||| | ||
| 008 | 230213s2021 ci |o |0|| ||eng | ||
| 024 | 7 | |2 doi |a 10.11613/BM.2021.020706 | |
| 035 | |a (HR-ZaNSK)001163329 | ||
| 040 | |a HR-ZaNSK |b hrv |c HR-ZaNSK |e ppiak | ||
| 041 | 0 | |a eng | |
| 042 | |a croatica | ||
| 044 | |a ci |c hr | ||
| 080 | 1 | |2 2011 | |
| 100 | 1 | |a Lenicek Krleza, Jasna |4 aut |9 HR-ZaNSK | |
| 245 | 1 | 0 | |a Seroprevalence of SARS-CoV-2 infection among children in Children"s Hospital Zagreb during the initial and second wave of COVID-19 pandemic in Croatia |h [Elektronička građa] |c Jasna Lenicek Krleza, Renata Zrinski Topic, Vladimir Stevanovic, Amarela Lukic-Grlic, Irena Tabain, Zrinjka Misak, Goran Roic, Bernard Kaic, Dijana Mayer, Zeljka Hruskar, Ljubo Barbic, Tatjana Vilibic-Cavlek. |
| 300 | |b Ilustr. | ||
| 504 | |a Bibliografija: | ||
| 504 | |a Summary. | ||
| 520 | |a The study aimed to investigate the prevalence and titres of anti-SARS-CoV-2 antibodies in children treated at the Children"s Hospital Zagreb in the first and the second wave of the COVID-19 pandemic. Statistical significance of difference at two time points was done to determine how restrictive epidemiological measures and exposure of children to COVID-19 infection affect this prevalence in different age groups.At the first time point (13th to 29th May 2020), 240 samples and in second time point (24th October to 23rd November 2020), 308 serum samples were tested for anti-SARS-CoV-2 antibodies by enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLIA). Confirmation of results and titre determination was done using virus micro-neutralization test. Subjects were divided according to gender, age and epidemiological history.Seroprevalence of anti-SARS-CoV-2 antibodies differs significantly in two time points (P = 0.010). In first time point 2.9% of seropositive children were determined and in second time point 8.4%. Statistically significant difference (P = 0.007) of seroprevalence between two time points was found only in a group of children aged 11-19 years. At the first time point, all seropositive children were asymptomatic with titre <8. At the second time point, 69.2% seropositive children were asymptomatic with titre ≥ 8.The prevalence of anti-SARS-CoV-2 antibodies was significantly lower at the first time point than at the second time point. Values of virus micro-neutralization test showed that low titre in asymptomatic children was not protective at the first time point but in second time point all seropositive children had protective titre of anti-SARS-CoV-2 antibodies. | ||
| 700 | 1 | |a Zrinski Topic, Renata |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Stevanovic, Vladimir |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Lukic-Grlic, Amarela |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Tabain, Irena |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Misak, Zrinjka |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Roic, Goran |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Kaic, Bernard |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Mayer, Dijana |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Hruskar, Zeljka |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Barbic, Ljubo |4 aut |9 HR-ZaNSK | |
| 700 | 1 | |a Vilibic-Cavlek, Tatjana |4 aut |9 HR-ZaNSK | |
| 773 | 0 | |t Biochemia medica (Online) |x 1846-7482 |g 31 (2021), 2 ; str. 283-294 |w nsk.(HR-ZaNSK)000655372 | |
| 981 | |b Be2021 | ||
| 856 | 4 | 0 | |u https://doi.org/10.11613/BM.2021.020706 |
| 856 | 4 | 0 | |u https://www.biochemia-medica.com/en/journal/31/2/10.11613/BM.2021.020706 |y Elektronička verzija članka |
| 856 | 4 | 0 | |u https://www.biochemia-medica.com/en/journal/31/2/10.11613/BM.2021.020706/fullArticle |y Elektronička verzija članka |
| 856 | 4 | 1 | |y Digitalna.nsk.hr |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/258884 |y Elektronička verzija članka |