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Evaluation of a new equation for estimating low-density lipoprotein cholesterol through the comparison with various recommended methods

Introduction: The accurate estimation of low-density lipoprotein cholesterol (LDL) is crucial for management of patients at risk of cardiovascularevents due to dyslipidemia. The LDL is typically calculated using the Friedewald equation and/or direct homogeneous assays. However, both methodshave thei...

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Permalink: http://skupni.nsk.hr/Record/nsk.NSK01001163348/Details
Matična publikacija: Biochemia medica (Online)
31 (2021), 1 ; str. 54-65
Glavni autori: Martínez-Morillo, Eduardo (Author), García-García, María, Concha, María Angeles Luengo, Varas, Luis Rello
Vrsta građe: e-članak
Jezik: eng
Online pristup: https://doi.org/10.11613/BM.2021.010701
Elektronička verzija članka
Elektronička verzija članka
Elektronička verzija članka
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024 7 |2 doi  |a 10.11613/BM.2021.010701 
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040 |a HR-ZaNSK  |b hrv  |c HR-ZaNSK  |e ppiak 
041 0 |a eng 
042 |a croatica 
044 |a ci  |c hr 
080 1 |2 2011 
100 1 |a Martínez-Morillo, Eduardo  |4 aut  |9 HR-ZaNSK 
245 1 0 |a Evaluation of a new equation for estimating low-density lipoprotein cholesterol through the comparison with various recommended methods  |h [Elektronička građa]  |c Eduardo Martínez-Morillo, María García-García, María Angeles Luengo Concha, Luis Rello Varas. 
300 |b Ilustr. 
504 |a Bibliografija: 
504 |a Summary. 
520 |a Introduction: The accurate estimation of low-density lipoprotein cholesterol (LDL) is crucial for management of patients at risk of cardiovascularevents due to dyslipidemia. The LDL is typically calculated using the Friedewald equation and/or direct homogeneous assays. However, both methodshave their own limitations, so other equations have been proposed, including a new equation developed by Sampson. The aim of this studywas to evaluate Sampson equation by comparing with the Friedewald and Martin-Hopkins equations, and with a direct LDL method.Materials and methods: Results of standard lipid profile (total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL) and triglycerides(TG)) were obtained from two anonymized data sets collected at two laboratories, using assays from different manufacturers (Beckman Coulter andRoche Diagnostics). The second data set also included LDL results from a direct assay (Roche Diagnostics). Passing-Bablok and Bland-Altman analysisfor method comparison was performed.Results: A total of 64,345 and 37,783 results for CHOL, HDL and TG were used, including 3116 results from the direct LDL assay. The Sampson andFriedewald equations provided similar LDL results (difference ≤ 0.06 mmol/L, on average) at TG ≤ 2.0 mmol/L. At TG between 2.0 and 4.5 mmol/L,the Sampson-calculated LDL showed a constant bias (- 0.18 mmol/L) when compared with the Martin-Hopkins equation. Similarly, at TG between4.5 and 9.0 mmol/L, the Sampson equation showed a negative bias when compared with the direct assay, which was proportional (- 16%) to the LDLconcentration.Conclusions: The Sampson equation may represent a cost-efficient alternative for calculating LDL in clinical laboratories. 
700 1 |a García-García, María  |4 aut  |9 HR-ZaNSK 
700 1 |a Concha, María Angeles Luengo  |4 aut  |9 HR-ZaNSK 
700 1 |a Varas, Luis Rello  |4 aut  |9 HR-ZaNSK 
773 0 |t Biochemia medica (Online)  |x 1846-7482  |g 31 (2021), 1 ; str. 54-65  |w nsk.(HR-ZaNSK)000655372 
981 |b Be2021 
856 4 0 |u https://doi.org/10.11613/BM.2021.010701 
856 4 0 |u https://www.biochemia-medica.com/en/journal/31/1/10.11613/BM.2021.010701  |y Elektronička verzija članka 
856 4 0 |u https://www.biochemia-medica.com/en/journal/31/1/10.11613/BM.2021.010701/fullArticle  |y Elektronička verzija članka 
856 4 1 |y Digitalna.nsk.hr 
856 4 0 |u https://hrcak.srce.hr/252375  |y Elektronička verzija članka 

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