Determination of nonsteroidal anti-inflammatory drugs (NSAIDs) in milk and fresh cheese based on the inhibition of cyclooxygenase

Summary: A biosensor for rapid determination of nonsteroidal anti-inflammatory drugs (NSAIDs) is described based on the inhibition of cyclooxygenase enzyme (both isoforms) by NSAIDs. The results show the full validity of the method, which has also been optimized by comparing the inhibition of two en...

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Permalink: http://skupni.nsk.hr/Record/nsk.NSK01000736221/Details
Matična publikacija: Food technology and biotechnology
47 (2009), 2 ; str. 172-177
Glavni autor: Campanella, Luigi (-)
Ostali autori: Di Persio, Giulia (-), Pintore, Manuela, Tonnina, Daniele, Caretto, Nicola, Martini, Elisabetta, Lelo, Dalina
Vrsta građe: Članak
Jezik: eng
Predmet:
Online pristup: Food Technology and Biotechnology
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245 1 0 |a Determination of nonsteroidal anti-inflammatory drugs (NSAIDs) in milk and fresh cheese based on the inhibition of cyclooxygenase /  |c Luigi Campanella, Giulia Di Persio, Manuela Pintore, Daniele Tonnina, Nicola Caretto, Elisabetta Martini, Dalina Lelo. 
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504 |a Bibliografija: 21 jed 
520 8 |a Summary: A biosensor for rapid determination of nonsteroidal anti-inflammatory drugs (NSAIDs) is described based on the inhibition of cyclooxygenase enzyme (both isoforms) by NSAIDs. The results show the full validity of the method, which has also been optimized by comparing the inhibition of two enzyme isoforms, COX-1 and COX-2, in the presence of different tested pharmaceutical drugs (diclofenac, naproxen, ibuprofen, tolmetin). Also, recovery trials were performed in milk and fresh cheese adulterated with known quantities of NSAIDs, always obtaining recovery values >88 % 
653 0 |a Ciklooksigenaza  |a Nesteroidni protuupalni lijekovi  |a Mlijeko  |a Svježi sir 
700 1 |a Di Persio, Giulia 
700 1 |a Pintore, Manuela 
700 1 |a Tonnina, Daniele 
700 1 |a Caretto, Nicola 
700 1 |a Martini, Elisabetta 
700 1 |a Lelo, Dalina 
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